Hygeia journal for drugs and medicines



Hygeia.J.D.Med, 2(1), 2010, 1-15


SiyadA. R

Departmentof Pharmacy Practice,  Crescent Collegeof  Pharmaceutical Sciences ,Kannur,Kerala, India, 670358    


  Article history: Received: 21 December 2009,accepted: 15 February 2010

 Sinusitis isthe fifth common diagnosis for which an anti biotic is prescribed and about $ 2billion is spent annually on medications to treat nasal and sinus problems.Diagnosis and treating sinusitis is therefore being very  important .Acute bacterial sinusitis usuallyoccurs following an upper respiratory infection that result in the  obstruction of the osteomeatal complex  , impaired mucociliary  clearance and production of secretions (L.J.Fajan et al ,1989.)

       Acute sinusitis is a common illness in primarycare .Studies have demonstrated the difficulty of making the differentialdiagnosis of acute purulent sinusitis based on clinical evaluations alone. This leads to  a significant overuse of antibiotics, whichin turn may contribute to increase bacterial resistance.   (Morten Lindback. et al.,2002). Sinus diseaseis inherently associated with  viralupper respiratory tract infections and occurs in 90% of  individuals with common cold. Although thediagnosis of acute bacterial sinusitis is usually based on  physical findings, no one sign or symptom iseither sensitive or specific for sinusitis. The predictive power can be significantlyimproved when all signs and symptoms  iseither sensitive or specific for sinusitis.  (Martin Desrosiers.  et al.,2002)There is solid evidence that a positive association between nasal allergyand acute or  chronic sinusitis in bothadult and children. (Shin- Wen Huang. et al., 2006 . Acute sinusitis frequentlyfollows  upper respiratory tractinfections. Sinusitis or an inflammation of one or more of the para nasalsinuses, affects  approximately 16% of USadults, resulting in nearly $ 5.8 billion in annual healthcare costs. (LauriaBarclay et al)


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