Hygeia journal for drugs and medicines


In vitro evaluation of anthelmintic efficacy of Trichilia and Ajuga species on Ascaridia galli
Hygeia.J.D.Med.Vol.2 (2), 2010, 43-53.  

Type of article: research article

Authors: G. Agarwal1*, A.K. Pant2 , and S.K. Hore1


1. Department of Pharmacology and Toxicology,  G. B. Pant University of Agriculture and Technology, Pantnagar, India, 263145 .
2..Department of Chemistry, G. B. Pant University of Agriculture and Technology, Pantnagar, India, 263145 .  

Article history:   
Received:  15 May 2010, 
Revised:  15 June 2010,
Accepted:  4 August 2010
Available online 20 Sep 2010.


The study was designed to evaluate the effect of the  methanol, chloroform, acetone and aqueous extracts of different parts of Trichilia connaroides, Ajuga bracteosa, Ajuga macrosperma, Ajuga parviflora of Indian Himalayan region and a reference drug albendazole on isometric contractions of the poultry worm Ascaridia galli. The frequency and amplitude of spontaneous muscular contractions of A. galli were recorded on the physiograph through force transducer. There was inhibition in amplitude and frequency of the contractile activity as compared to control in dose dependent manner by methanol extracts of seeds (IC50 3.93±0.70),  pericarps (IC507.09± 2.64),  aqueous extract of roots (IC50 6.40± 4.74) of T. connaroides, methanol extracts of A. parviflora roots  (IC50 16.79± 2.93)  A. macrosperma roots (IC501.73± 0.02) and A. bracteosa aerial parts  (IC50 4.49± 0.72). These observations indicated the paralytic effect of the extracts on A. galli. There was no inhibition contractile activity by chloroform extract of seeds, acetone extract of leaves of  T. connaroides and methanol extract of A. bracteosa roots on autorythmicity of A. galli.

Key words
: T. connaroides; Ajuga bracteosa ;A. macrosperma ;A.parviflora ; Ascaridia galli ; Albendazole; Autorythmicity

Article outline:

1. Introduction
2. Materials and methods
4. Isometric mounting of A. galli and mechanical recording of the spontaneous muscular activity
5. Effect of different extracts and albendazole on autorythmicity of A. galli
6.  Statistical analysis
7. Results and discussion
8. References


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