Abstract
Visible Spectrophotometric method for the estimation of Cefepime
Hygeia.J.D.Med.Vol.2 (2), 2010, 32-37.
Type of article: research article
Authors: Minu Sujith1, Sujith Abraham1*and Madhu.C.Divakar2
Affiliation:
1. Nirmala College of Pharmacy, Muvattupuzha, Ernakulam , Kerala , India - 686661
2. Crescent College of Pharmaceutical Sciences ,Payangadi.P.O , Kannur, Kerala , India 670358 .
Article history:
Received: 10 January2010,,
Revised: 25April2010,
Accepted:18 june2010 ,
Available online 31 July 2010.
Abstract:
A simple, accurate and reproducible visible spectrophotometric method was developed for the estimation of cefepime in pure and vial formulation. Cefepime with 1-Chloro-2,4-dinitrobenzene in presence of dimethyl sulfoxide at 45oC have formed a yellow colored complex having maximum absorbance at 420nm.The calibration graph was linear in the range 20µg/ml to50µg/ml.
Keywords:
Visible spectrophotometry, Cefepime, 1-Chloro-2, 4-dinitrobenzene, Dinitrobenzene
Article outline:
1. Introduction
2. Experimental
2.1. Instruments used
2.2. Chemicals and reagents
2.3. Preparation of standard drug solution
2.4. Analysis of pharmaceutical formulation
2.5. Recovery studies
3. Results and discussion
4. Conclusion
5. References
Graphical outline:
Beer's -Lambert's plot of cefepime at 420 nm
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