Hygeia journal for drugs and medicines


The Hepatoprotective Effect of The Polyphenolic Compounds in the Roots of Trichilia connaroides Wight and Arn
Hygeia.J.D.Med.Vol.2 (2), 2010, 22-31. 

Type of article: research article

Authors: Garima Agarwal1*, Anil Kumar Pant1 , and Subroto Kumar Hore2 .


1.Department of Chemistry , G. B. Pant  University of Agriculture and Technology, Pantnagar , India - 263145 .

2.Department of Pharmacology and Toxicology, G. B. Pant University of Agricultur and Technology, Pantnagar, India - 263145 .

Article history:

Received:  15 May 2010, 
Revised:  20 June 2010,
Accepted:  3 August 2010
Available online: 20 Sep 2010.


Trichilia species are used in the treatment of liver disorders and as a tonic in the traditional medicine. The present study was designed to evaluate the hepatoprotective effects of aqueous extract of T. connaroides roots on carbon tetrachloride induced hepatotoxicity in comparision with the known hepatoprotective agent Liv-52. Carbon tetrachloride induced changes in serum enzymatic levels of aspartate amino transferase , alanine amino transferase , alkaline phosphatase  and total protein were restored towards normal levels by the extract. The biochemical observations were supported by the histopathological examination of rat liver sections. The results indicate that the extract offers hepatoprotection in a dose-dependent manner. The effect was comparable to that produced by Liv-52.  Simultaneously, in-vitro anti-oxidant activity of the extract as evaluated in terms of reducing power, radical scavenging activity and chelating activity on Fe+2 also support its hepatoprotective action. Phytochemical examination of the extract revealed the presence of antioxidant phenolics.

Keywords:  Trichilia connaroides, Carbon tetrachloride, Hepatoprotective activity, Antioxidant activity,  Histopathology.

Article outline:

1.  Introduction
2.  Materials and methods
3.  Hepatoprotective activity
4.  Anti oxidant activity
5.  Phytochemical analysis
6.  Statistical analysis
7.  Results and discussion
8.  Conclusion
9.  References

Graphical outline:
Normal hepatic cells ( x 200 ) 

Liver cells treated with CCl4
  (0.5 ml/ kg ).

Liver cells treated with CCl4 (0.5 ml/ kg) and 

100 mg /kg ARE (Aqueous Root Extract of T. connaroides)

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