Hygeia journal for drugs and medicines


Evaluation of In-vitro vector control activity of Physalis angulata.
Hygeia.J.D.Med.Vol.2 (2), 2010, 14-21.  

Type of article : research article

Sandhya.S1, Jafferi S.A.H1 , Vinod K.R1, Ottilia Banji1, David Banji1, Chaitanya R.S.N.A.K.K1, Chandrasekhar J1, Venkataramana.K2 . 


1. Nalanda College of Pharmacy, Nalgonda, Andhra.Pradesh., India.
2. A.S.N Pharmacy College, Tenali, Andhra.Pradesh., India.

Article history:

Received:  15 May 2009, 

Revised:  16December 2009,
Accepted: 23March 2010
Available online 20 Sep 20



The present study was undertaken to evaluate anthelmintic and larvicidal activity of crude ethanolic leaf extract of Physalis angulata belonging to family Solanaceae. Pheretima posthuma was used as the test worms. Various concentrations of ethanolic extracts were tested in the anthelmintic screening, which involved determination of time of paralysis (P) and time of death (D) of the worms. Piperazine citrate was included as standard reference and distilled water as control. In the case of larvicidal activity the study was conducted on Culex quniquefasicatus species of mosquito larvae and the rate of larval mortality was calculated. The results indicated that the crude ethanolic extract significantly demonstrated paralysis and also caused death of the helminthes especially at higher concentration of 50 mg/ml, as compared to standard reference piperazine citrate. Similarly very optimistic results were observed for Culex quniquefasicatus species of mosquito larvae and LC50 value was calculated as 51.8802 mg/l.

Keywords: Anthelmintic, larvicidal, Physalis angulata, Pheretima posthuma,Culex quniquefasicatus

Article outline:

1.  Introduction
2.  Extraction
3.  Anthelmintic assay
4.  Results and discussion
5.  Conclusion
6.  References

Graphical Outline:
(Graph for Finneys analysis) 

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