Abstract
PPAR LIGANDS AND ITS IMPLICATION IN CANCER – A REVIEW
Thenuclear hormone receptor superfamily includes one of the ligand-activatedtranscription factors called peroxisome proliferator-activated receptors(PPARs). PPAR has three isoform PPARα, PPARδ, PPARγ. PPARα is mainly expressedin the liver, where it triggers the breakdown of fatty acids. PPARδ is widelyexpressed and associated with both keratinocyte differentiation and fatty acidoxidation. PPARγ found in adipose tissue is essential forthe differentiation of adipocytes. By increasing insulin sensitivity, PPARγcontributes to glucose metabolism and one of the targets for type 2 diabetestreatment. PPARs have the capability to bind a variety of natural and syntheticligands such as thiazolidinedione. PPARs also play a role in the regulation ofcancer cell growth. Here, in this review, we focus on new PPAR ligands and itsimplication in tumor growth.