Hygeia journal for Drugs and Medicines

Abstract

DESIGN AND CHARACTERISATION OF DELAYED RELEASE TABLETS OF SERRATIOPEPTIDASE USING SOLID DISPERSION TECHNIQUE
The objective of this work was designing and characterization of delayed release tablets of Serratiopeptidse by solvent evaporation technique using rota vapour and preparation of solid dispersion. FTIR studies showed there is no drug interaction with excipients Eudragit L-100, ethyl cellulose, Micro Crystalline Cellulose, Talc, Magnesium stearate. Serratiopeptidse along with polymer Eudragit L-100 with different ratios 1:0.1, 1:0.2,1:0.3,1:0.4,1:0.5,1:0.6,1:0.7,1:0.8 was subjected to solid dispersion. Solid dispersion technology is the science of dispersing one or more active ingredients in an inert matrix in the solid state to formulate sustained release preparation of soluble drugs by dispersing the drug in poorly soluble or insoluble carrier. Serratiopeptidase delayed release tablets were prepared by wet granulation method. The prepared tablets were evaluated for hardness, weight variation, friability, drug content and disintegration time. All these parameters were found to be within the pharmacopoeia limits for all formulations. In -vitro dissolution study was carried out for all the formulations. The drug release was found to be 99.98 ± 0.12% at 4 hrs. Comparative in vitro dissolution study of F-II formulation showed better drug release than the marketed product.





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