Hygeia journal for drugs and medicines


Synthesis and Antioxidant activity of novel Pyrazoline derivatives

Hygeia.J.D.Med 2018; 10(1):43-49 
DOI: 10.15254/H.J.D.Med.10.2018.177.

B.C. Revanasiddappa*, M.Vijay Kumar, Hemanth Kumar

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India.

Plan:  A novel series of pyrazolines were synthesized through chalcones. The synthesized compounds were evaluated for various antioxidant activities. 
Preface:  Pyrazolines belongs to five-membered nitrogen classes of compounds. Pyrazolines were reported with widespread chemotherapeutic activities. 
Methodology: A new series of Chalcones (2a-j) were prepared by reacting substituted aldehydes and ketones in alcohol medium in presence of NaOH. The chalcones (2a-j) undergoes selective cyclization with benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1, 3, 5-trisubstituted Pyrazolines (3a-j). The new compounds were assigned on the basis of 1H-NMR, IR and Mass spectral data. The newly synthesized compounds were screened for their In-Vitro antioxidant activity by DPPH, superoxide and nitric oxide methods. 
Outcome: Some of the tested compounds 3e, 3g, and 3f showed moderate activity when compared to the standard drug ascorbic acid. 
Keywords: Pyrazolines, benzhydrazide, chalcones, antioxidant activity


B.C. Revanasiddappa M.Pharm, Ph.D
Department of Pharmaceutical Chemistry, 
NGSM Institute of Pharmaceutical Sciences of 
Nitte -Deemed to be University, 
Paneer, Deralakatte, Mangalore-575 018,
Karnataka, India
Mobile- 09448953198

Article History

Received: 10 February 2018,   
Revised:  17 May 2018
Accepted: 20 April 2018, 
Available online: 15 September 2018

Article citation
B.C. Revanasiddappa*, M.Vijay Kumar, Hemanth Kumar. Synthesis and Antioxidant Activity of Novel Pyrazoline Derivatives. Hygeia.J.D.Med 2018; 10(1):43-49. Available from http://www.hygeiajournal.com, DOI: 10.15254/H.J.D.Med.10.2018.177.



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