Abstract
Synthesis and Antioxidant activity of novel Pyrazoline derivatives
Hygeia.J.D.Med 2018; 10(1):43-49
DOI: 10.15254/H.J.D.Med.10.2018.177.
B.C. Revanasiddappa*, M.Vijay Kumar, Hemanth Kumar
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India.
Plan: A novel series of pyrazolines were synthesized through chalcones. The synthesized compounds were evaluated for various antioxidant activities.
Preface: Pyrazolines belongs to five-membered nitrogen classes of compounds. Pyrazolines were reported with widespread chemotherapeutic activities.
Methodology: A new series of Chalcones (2a-j) were prepared by reacting substituted aldehydes and ketones in alcohol medium in presence of NaOH. The chalcones (2a-j) undergoes selective cyclization with benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1, 3, 5-trisubstituted Pyrazolines (3a-j). The new compounds were assigned on the basis of 1H-NMR, IR and Mass spectral data. The newly synthesized compounds were screened for their In-Vitro antioxidant activity by DPPH, superoxide and nitric oxide methods.
Outcome: Some of the tested compounds 3e, 3g, and 3f showed moderate activity when compared to the standard drug ascorbic acid.
Keywords: Pyrazolines, benzhydrazide, chalcones, antioxidant activity
Correspondence:
B.C. Revanasiddappa M.Pharm, Ph.D
Department of Pharmaceutical Chemistry,
NGSM Institute of Pharmaceutical Sciences of
Nitte -Deemed to be University,
Paneer, Deralakatte, Mangalore-575 018,
Karnataka, India
revan@nitte.edu.in
Mobile- 09448953198
Article History
Received: 10 February 2018,
Revised: 17 May 2018
Accepted: 20 April 2018,
Available online: 15 September 2018
Article citation
B.C. Revanasiddappa*, M.Vijay Kumar, Hemanth Kumar. Synthesis and Antioxidant Activity of Novel Pyrazoline Derivatives. Hygeia.J.D.Med 2018; 10(1):43-49. Available from http://www.hygeiajournal.com, DOI: 10.15254/H.J.D.Med.10.2018.177.