Hygeia journal for drugs and medicines


Simultaneous estimation of Curcumin and Gefitinib in bulk by using RP-HPLC technique with PDA detector.

 2018; 10(1):1-8 
DOI: 10.15254/H.J.D.Med.10.2018.172.

Sagar Kishor Savale
Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425-405, MS, India.

Plan: RP-HPLC method development and validation for the simultaneous estimation of curcumin and Gefitinib in bulk.
Preface: RP-HPLC chromatographic methods have been widely employed in the determination of individual components in a mixture or fixed dose combination. For the ternary mixture containing Curcumin and Gefitinib, no chromatographic method for simultaneous evaluation has been reported so far. Thus our aim is to develop a simultaneous estimation method for curcumin and gefitinib by using an RP-HPLC method using a PDA detector.
Methodology: The method was validated as per ICH guidelines. The recovery studies confirmed the accuracy and precision of the method.
Outcome: The proposed method was found to be accurate, repeatability and consistent. It was successfully applied for the analysis of the drug in the marketed formulation and could be effectively used for the routine analysis of formulation containing the drug without any alteration in the chromatography conditions.
Keywords: Isocratic, Curcumin, RP-HPLC, Gefitinib, Validation, Simultaneous estimation.


Sagar Kishor Savale, M.Pharm 
Department of Pharmaceutics,
R. C. Patel Institute of Pharmaceutical
Education& Research, Shirpur, 425405, Dist. Dhule, Maharashtra, India. 

Rid: G-1426-2017

Article History

Received:30 September 2017,  
Revised:  12 January 2018
Accepted:5 April 2018,
Available online: 15 September 2018

Article citation

Sagar Kishor Savale. Simultaneous estimation of curcumin and gefitinib in bulk by using an RP-HPLC technique with PDA detector. Hygeia.J.D.Med 2018; 10(1):1-8.Available from http://www.hygeiajournal.com, DOI: 10.15254/H.J.D.Med.10.2018.172.


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