Abstract
New Spectrophotometric Method for the Estimation of Atorvastatin calcium and Aspirin using Urea as Hydrotropic solubilizing agent.
Hygeia.J.D.Med 2018; 9(2):11-19.
DOI: 10.15254/H.J.D.Med.9.2018.169
Shyni Bernard* , Rani Sebastian , Babitha MC.
College of Pharmaceutical Sciences, Govt.Medical College, Kottayam,Kerala, India .
Plan:An analytical method for the simultaneous determination of Atorvastatin and Aspirin in capsule dosage form using 1.5M urea as hydrotropic solubilizing agent is described.
Prologue: The method is simple, fast, & accurate and precludes the use of corrosive solvents and can be used for the routine analysis of commercial combinations of Atorvastatin and Aspirin.
Methodology:The developed method used the simultaneous equation method (method-A)using 243 nm and 233 nm as absorbance maxima for ATR and ASP respectively and Q-absorbance ratio method (method-B), which is based on the measurement of absorptivity at iso-absorptive point 239 nm and 243 nm (absorption maximum of Atorvastatin). The calibration curves for both drugs were found to be linear in the concentration range of 10-50µg/ml.
Outcome:The proposed method has been applied successfully for the simultaneous determination of Atorvastatin and Aspirin in capsule dosage form. The mean recovery of the drugs from the combination tablets was found to be 98.83 %for Atorvastatin and 97.77 % for Aspirin for method-A and 98.09 % and 98.06 % for method-B respectively. No significant interference was observed from urea and other excipients commonly used in the formulation.
Key words: Aspirin, Atorvastatin, Urea, Hydrotropy.
Correspondence
Shini Bernard M.Pharm, PhD
College of Pharmaceutical Sciences, Govt.Medical College, Kottayam,
Kerala, India ,
E-mail: shynibernard@gmail.com
Rid: B-8471-2013
Article history
Received: 10 September 2017
Revised: 20 October 2017
Accepted: 19 November 2017,
Available online: 4 January 2018
Article citation
Shyni Bernard, Rani Sebastian, Babitha MC. New spectrophotometric method for the estimation of Atorvastatin calcium and Aspirin using urea as hydrotropic solubilizing agent. Hygeia.J.D.Med 2018; 9(2):11-19.Available from http://www.hygeiajournal.com , DOI: 10.15254/H.J.D.Med.9.2018.169
UV spectrum of Atorvastatin
UV spectrum of Aspirin
Overlain UV spectrum of Atorvastatin & Aspirin