Hygeia journal for drugs and medicines


New Spectrophotometric Method for the Estimation of Atorvastatin calcium and Aspirin using Urea as Hydrotropic solubilizing agent.

2018; 9(2):11-19.
DOI: 10.15254/H.J.D.Med.9.2018.169

Shyni Bernard* , Rani Sebastian , Babitha MC.

College of Pharmaceutical Sciences, Govt.Medical College, Kottayam,Kerala, India . 

Plan:An analytical method for the simultaneous determination of Atorvastatin and Aspirin in capsule dosage form using   1.5M urea as hydrotropic solubilizing agent is described.
Prologue: The method is simple, fast, & accurate and precludes the use of corrosive solvents and can be used for the routine analysis of commercial combinations of Atorvastatin and Aspirin.
Methodology:The developed method used the simultaneous equation method (method-A)using 243 nm and 233 nm as absorbance maxima for ATR and ASP respectively and  Q-absorbance ratio method (method-B), which is based on the  measurement of absorptivity at iso-absorptive  point 239 nm  and 243 nm (absorption maximum of Atorvastatin). The calibration curves for both drugs were found to be linear in the concentration range of 10-50µg/ml.
Outcome:The proposed method has been applied successfully for the simultaneous determination of Atorvastatin and Aspirin in capsule dosage form. The mean recovery of the drugs from the combination tablets was found to be 98.83 %for Atorvastatin and 97.77 % for Aspirin for method-A and 98.09 % and 98.06 % for method-B respectively. No significant interference was observed from urea and other excipients commonly used in the formulation.
Key wordsAspirin, Atorvastatin, Urea, Hydrotropy. 

Shini Bernard M.Pharm, 
College of Pharmaceutical Sciences, Govt.Medical College, Kottayam,
Kerala, India , 
E-mail: shynibernard@gmail.com
Rid: B-8471-2013

Article history

Received: 10 September 2017  
Revised: 20 October 2017

Accepted: 19 November 2017, 
Available online: 4 January 2018

Article citation

Shyni Bernard, Rani Sebastian, Babitha MC. New spectrophotometric method for the estimation of Atorvastatin calcium and Aspirin using urea as hydrotropic solubilizing agent. Hygeia.J.D.Med 2018; 9(2):11-19.Available from http://www.hygeiajournal.com , DOI: 10.15254/H.J.D.Med.9.2018.169

            UV spectrum of  Atorvastatin


             UV spectrum of  Aspirin


      Overlain UV spectrum of  Atorvastatin & Aspirin


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