Abstract
Protective effect of an herbal extract in amlodipine induced testicular dysfunction in rats.
Hygeia.J.D.Med. 2017; 9 (1):22-42
DOI:10.15254/H.J.D.Med.9.2017.162
Shini Dominic* and V.Padmaja.
College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram, Kerala-695011
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ABSTRACT
Plan: To verify the protective effects of the ethanolic extract of Asteracantha longifolia seeds in Amlodipine induced testicular dysfunction in rats.
Preface: The widely used Dihydropyridine type calcium channel blockers like Amlodipine have reported to be causing some reproductive toxicity in males. But no studies have been made so far to nullify the toxicity of this widely prescribed group of drugs. So, an attempt is done here to nullify the reproductive toxicity of Amlodipine.
Methodology: Biochemical and histological parameters of testes and different sperm parameters were analysed in ten different groups of young Wister albino rats treated with Amlodipine alone, and Amlodipine along with two different doses of ethanolic extract of Asteracantha longifolia seeds for three different periods of drug administration.
Outcome: Co-administration of the ethanolic extract of Asteracantha longifolia seeds was found to be providing a significant protection (P<0.05) against Amlodipine induced testicular dysfunction in rats.
Keywords: Amlodipine, Asteracantha longifolia, testicular dysfunction
Correspondence
Shini Dominic M.Pharm, PhD.
College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram, Kerala-695011
shinidm@gmail.com
Contact: 0091 9446304101
Researcher ID: C-3510-2013
Article History: Received: 22 January 2017, Revised: 20 March 2017Accepted: 12 May 2017, Available online: 5 July 2017
Article citation
Shini Dominic * and V.Padmaja. Protective effect of an herbal extract in amlodipine-induced testicular dysfunction in rats. Hygeia.J.D.Med 2017; 9(1):22-42. Available from http://www.hygeiajournal.com , DOI: 10.15254/H.J.D.Med.9.2017.162
