Hygeia.J.D.Med.9(1) July 2017 - December 2017

Abstract

Protective effect of an herbal extract in amlodipine induced testicular dysfunction in rats.


Hygeia.J.D.Med. 2017; 9 (1):22-42
DOI:10.15254/H.J.D.Med.9.2017.162
 

Shini Dominic* and V.Padmaja.

College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram, Kerala-695011

Google Scholar 

ABSTRACT


Plan: To verify the protective effects of the ethanolic extract of Asteracantha longifolia seeds in Amlodipine induced testicular dysfunction in rats.
Preface: The widely used Dihydropyridine type calcium channel blockers like Amlodipine have reported to be causing some reproductive toxicity in males. But no studies have been made so far to nullify the toxicity of this widely prescribed group of drugs. So, an attempt is done here to nullify the reproductive toxicity of Amlodipine.
Methodology: Biochemical and histological parameters of testes and different sperm parameters were analysed in ten different groups of young Wister albino rats treated with Amlodipine alone, and Amlodipine along with two different doses of ethanolic extract of Asteracantha longifolia seeds for three different periods of drug administration.
Outcome Co-administration of the ethanolic extract of Asteracantha longifolia seeds was found to be providing a significant protection (P<0.05) against Amlodipine induced testicular dysfunction in rats.

Keywords: AmlodipineAsteracantha longifolia, testicular dysfunction


Correspondence

Shini Dominic M.Pharm, PhD.

College of Pharmaceutical Sciences, Govt. Medical College, Thiruvananthapuram, Kerala-695011

 

shinidm@gmail.com
Contact: 0091 9446304101

Researcher ID: C-3510-2013
 

Article History: Received: 22 January 2017,   Revised: 20 March 2017Accepted: 12 May 2017, Available online: 5 July 2017

 

Article citation

Shini Dominic * and V.Padmaja. Protective effect of an herbal extract in amlodipine-induced testicular dysfunction in ratsHygeia.J.D.Med 2017; 9(1):22-42. Available from http://www.hygeiajournal.com , DOI: 10.15254/H.J.D.Med.9.2017.162





Hygeia J. D. Med.





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