Abstract
Formulation, Evaluation and Optimization of Novel Silver Sulfadiazine Loaded Film Forming Hydrogel for Burns
Hygeia.J.D.Med. 2016; 8 (2):1-10
DOI:10.15254/H.J.D.Med.8.2016.156
Saranya TV, and Manoj K *
College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode,Kerala-673008
Received:25 August 2016,
Revised:20 September 2016
Accepted:12 October 2016,
Available online: 30 November 2016
Plan: Formulation, evaluation and optimization of Silversulfadiazine loaded film forming hydrogel using different hydrophilic polymers for the treatment of burns.
Preface: Burn injuries are very complex. One of the golden treatments in topicalburn is silver sulfadiazine (SSD).The film forming hydrogels (FFHs) are non-solid dosage forms that produce a flexible, occlusive film in-situ afterapplication on the skin or any other body surface.
Methodology: The hydrogel matrix was prepared with combinations of PVA & PVP, HPMCE5LV, and HPMC E15LV. The prepared FFHs were evaluated for their variousphysicochemical properties. The optimized formulation was selected by antimicrobial activity by agar diffusion technique. The in-vitro drug release study of optimized formulation was carried out and analyzed by potentiometric titrations.
Outcome: All the formulations showed better antimicrobial activity when compared with marketed SSD cream. The formulation F3 was found to be the optimized formulation.
Key words Film forming hydrogel, Silver sulfadiazine, Potentiometry
Article citation
Corresponding author email: manoj4880@gmail.com
Hygeia.J.D.Med. Vol.8 (2), November2016 © All rights reserved
Hygeia journal for drugs and medicines, 2229 3590
Researcher ID: P-5411-2016
SEM image of formulation F3 at 3000 magnification