Hygeia journal for drugs and medicines


A Comparative Evaluation of in Vitro Antacid activity of two Tephrosia Species using Modified Artificial Stomach Model.

Hygeia.J.D.Med 2015; 7(2):9-17

Sandhya S1*, Venkata Ramana K2,Vinod K.R3


1.Department of Pharmacognosy, St. James College of PharmaceuticalSciences, River Bank, Chalakkudy, Thrissur District, Kerala, India
2. Department of Pharmacognosy, ASN Pharmacy College, Tenali,Andhra Pradesh, India.
3. Department of Pharmaceutics, Sanjo College of Pharmaceutical Studies, Palakkad, Kerala, India

Corresponding author email:sanpharm@gmail.com          

Plan: The methanol extracts of Tephrosia calophylla and Tephrosia maxima (Fabaceae) roots were assessed for the antacid activity by using self-fabricated modified artificial stomach model.

Preface: Tephrosia calophylla and Tephrosia maxima are two medicinal plants prevalent to AndhraPradesh, Karnataka and Tamil Nadu. These two plants are used widely in folklore medicine for their antiulcer activity.

Methodology: The preliminary chemical tests performed for the extracts showed the presence of tannins, flavonoids, glycosides, saponins and carbohydrates. Then they were evaluated for the antacid potencies by working on the parameters like determination of pH of the prepared extracts, neutralizing effects on artificial gastric acids, duration of consistent neutralization effect on artificial gastric acids and neutralization capacity. Two commercially available antacids were used as the standard.

Outcome: The methanolic extract T.maxima showed potent antacid activity when compared to T.calophylla and the two standards.  Hence T.maxima can be considered as a potent substitute for the synthetic antacids that are well reputed for unwanted side effects. Further investigations on in vivo preclinical and clinical studies are yet to be performed.

Key words: Artificial gastric juice, Antacid, Flavonoids, Fordtran’s model, Vatier’s artificial stomach model.

Article citation 

Sandhya S*, Venkata Ramana K, Vinod K.RA comparative evaluation of in vitro antacid activity of two
Tephrosia species using modified artificial stomach model. Hygeia.J.D.Med 2015;7(2):9-17. Available from http://www.hygeiajournal.com / Article ID-Hygeia.J.D.Med/146/15.   DOI: 10.15254/H.J.D.Med.7.2015.146.


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