Abstract

Synthesis and in-vitro Anti-platelet aggregation activity of some New substituted Thiophenes

Hygeia.J.D.Med.5 (2) 87-96 

Jagadish ER1, Mohan S1, Saravanan J1, Satyendra D2*, Swetha Sree P1, Apurba T2,   Manoj K3, Rama Kanta S4

Article ID- Hygeia.J.D.Med/113/13.

ABSTRACT

Plan: To synthesize some novel 2-amino thiophenes with various substitutions at 2-amino position for anti-platelet aggregation activity.

Preface: Various substituted and condensed thiophenes are reported to possess a wide variety of biological and pharmacological activities such as antibacterial, antifungal, anti-inflammatory, anti-platelet aggregation activity, antipyretic, antitumor and so on. Thus a series of new thiophenes have synthesized with various substituents at 2-amino position and screened for anti-platelet aggregation activity.

Methodology: The starting material (JMS-2) was prepared by the application of versatile Gewald reaction. It was then derivatized to various Schiff bases JMS-2(a-m) by reacting with various substituted aromatic aldehydes. The synthesized new compounds were characterized by MP, TLC, IR, NMR and Mass spectra and were screened for their In-vitro anti-platelet aggregation activity by GVR Born method using Heparin as the standard.

Outcome: Compound JMS-2a, JMS-2b, JMS-2d and JMS-2i showed good % inhibition and were found to be more significant.

Keywords: 2-amino thiophene, Gewald reaction, anti-platelet aggregation.

Jagadish ER, Mohan S,Saravanan J, Satyendra D*, Swetha Sree P, Apurba T,   Manoj K, Rama Kanta S. Synthesis and in-vitroAnti-platelet aggregation activity of some New substituted Thiophenes, Hygeia.J.D.Med 2013;5(2):87-96.Availablefrom   http://www.hygeiajournal.com / ArticleID- Hygeia.J.D.Med/113/13.