Hygeia journal for drugs and medicines


Evaluation of Phoenix dactylifera fruits for Antiurolithiatic activity


Hygeia.J.D.Med. 2013; 5(1):135-140

Challa Srinivas Reddy*, Pradeep Vardhaman

VaagdeviCollege of Pharmacy,Hanamkonda, Warangal, Andhra Pradesh., India.


Article history: Received: 5 January 2013,   revised: 20 January 2013, accepted: 15February 2013, Available online: 3 April 2013



Plan:Phoenix dactylifera L. of Arecaceae (Palmae) family is consumed worldwide as an edible fruit. Reviews indicated the use of fruit as antioxidant, anticancer, antilipaemic and antidiabetic in many traditional treatments.In the present study the antiurolithiatic activity of P. dactylifera fruits are reported.

Materials and Methods: Then-Butanol and Aqueous extract preparations were made and administered as test compounds,Cystone as reference standard in five groups. Ethylene glycol induced hyperoxaluria is selected as a screeningmethod for induction of kidney stones and the levels of creatinine, urea and uricacid are analysed.

Outcome: The n-butanol and aqueous extracts of P. dactylifera fruits in the doses of 200 mg/kg reduced creatinine, urea, uric acid levels,significantly  in comparison with the control.  But both the extracts showed results less than the standard drug 'Cystone' and the n-butanol extract was more effective than aqueous extract to decrease urea and uric acid levels.Among these two extracts the n-butanol extract exhibited more antiurolithiatic activity.

Keywords: Phoenix dactylifera, Ethylene Glycol, Urea, Uric Acid,Antiurolithiatic Activity.




ChallaSrinivas Reddy, Pradeep Vardhaman .Evaluation of Phoenix dactylifera fruits for Antiurolithiatic activity. Hygeia.J.D.Med. 2013; 5(1):135-140.Available at   http://www.hygeiajournal.com / Article ID- Hygeia.J.D.Med/98/13



For Correspondence::challa_cnu@yahoo.com   ,
Contact: +91-9885108060

Hygeia.J.D.Med. Vol.5 (1), April 2013
© 2013, Hygeia journal for drugs and medicines,
Allrights reserved.  22293590, 0975
Researcher ID:  K-5130-2012A


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