Abstract

Anti-inflammatory effect of Abyssinone V-4'-methyl ether on acute and chronic inflammation models

Hygeia.J.D.Med. 2013; 5(1):121-128

S.D. Sokeng1*, E. Talla2,V. Jeweldai1, A.J.G Yaya3, J. Koube1, F.Dongmo1, M.Goulimé1, J.T. Mbafor4

Article history: Received: 29 January 2013,   revised: 20 February 2013, accepted: 5 March 2013, Available online: 3 April 2013

Abstract

Plan:Anti-inflammatory evaluation of abyssinone V-4’-methyl ether.

Prologue: The anti-inflammatory activity of abyssinone V-4'-methyl ether, a natural prenylated flavonoid isolated from the bark of Erythrina droogmansiana (Leguminosae) was evaluated using acute and chronic inflammation models in vivo namely carrageenan-induced paw edema in rats, xylene induced-ear edema in mice and cotton pellets-induced granuloma formation in rats.

Methodology: Oral administration of abyssinoneV-4'-methyl ether at doses of 2.5, 5 and 10 mg/kg produced a dose-related inhibition of edema formation in the carrageenan induced-paw edema test inrats.

Outcome: The highest dose (10 mg/kg) of the compound induced an inhibition of 71.43% compared to 61.90% inhibition obtained with dexamethasone (2.5 mg/kg). In the xylene induced-ear edema in mice, abyssinone V-4'-methyl ether also produced a dose-dependent effect with a maximum inhibition of 62.25% obtained with the dose 10 mg/kg. In the chronic test, abyssinone V-4'-methyl ether at similar doses strongly inhibited the granulomatous tissue formation in cotton pellet-induced granuloma model inrats. These results suggest the anti-inflammatory properties of abyssinoneV-4'-methyl ether. This is the first time that the anti-inflammatory activity of this prenylflavanone is reported.

Keywords: Abyssinone V-4'-methyl ether,anti-inflammatory activity, carrageenan-induced paw edema, xylene induced ear edema, cotton pellet-induced granuloma.

D. Sokeng, E. Talla, V. Jeweldai,A.J.G Yaya, J. Koube, F. Dongmo,  M.Goulimé, J.T. Mbafor. Anti-inflammatory effect of abyssinone V-4'-methyl ether on acute and chronic inflammation models.Hygeia.J.D.Med. 2013; 5(1):121-128.  Available at http://www.hygeiajournal.com / Article ID- Hygeia.J.D.Med/96/13