Abstract

Anti diabetic activity of Dolichos lablab (seeds) in Streptozotocin- Nicotinamide induced diabetic rats.

Hygeia.J.D.Med. 2013; 5(1): 32-40.

Krishnaveni kante and Challa Srinivas Reddy

Vaagdevi college of Pharmacy, Ramnagar, Hanamkonda, Warangal-District. Andrapradesh, India.

Article history: Received: 12 November 2012,   revised:  23 December 2012, accepted:  5February 2013, Available online: 3 April 2013

Abstract

Plan: The present study was designed to investigate the anti diabetic activity of methanolic extract of Dolichos lablab seeds.

Preface: In traditional medicine plants are generally used for treatment of various acute and chronic disease and abnormalities in the body. Due to the present fast life of the human a drastic increase in chronic disease conditions mainly diabetes has been determined. The present study therefore justifies its use in the folklore remedies as an anti diabetic drug of natural origin.

Methodology: Anti diabetic activity was evaluated by Streptozocin-Nicotinamide induced diabetic model. The methanolic extract of the seeds of Dolichos lablab was given by Oral route at doses of 200 mg/kg and 400 mg/kg b.wt.

Outcome: Treated diabetic rats with MEDL dose dependely(P<0.001) reduced blood glucose levels, total cholesterol, triglycerides, SGPT, SGOT levels compared to untreated diabetic rats in STZ induced diabetic model. MEDL 400mg/kg b.wt was found to possess more promising antidiabetic activity compared to 200mg/kg b.wt

Key words: Dolichos lablab seeds, Streptozotocin, type 2 diabetes.

Krishnaveni kante and Challa Srinivas Reddy. Anti diabetic activity of Dolichos lablab (seeds) in Streptozotocin- Nicotinamide induced diabetic rats. Hygeia.J.D.Med. 2013; 5(1): 32- 40.  Available from   http://www.hygeiajournal.com / Article ID- Hygeia.J.D.Med/86/13