Hygeia journal for drugs and medicines


Formulation and Evaluation of Floating tablets of Theophylline

Hygeia.J.D.Med.2013; 5(1):23-31.

C.Bijumol*, Helen William, Jose Kurien and Thomas Kurian

College of Pharmaceutical Sciences, Govt. Medical College, Kottayam,Kerala

Article history: Received: 10 December 2012,  revised: 14 January 2013, accepted: 1 February 2013, Available online: 3 April 2013


Plan: Formulation of oral gastro retentive floating tablets of Theophylline.

Prologue: The primary aim of the present study is to design a sustained release gastro retentive oral dosage form using intra gastric floating as formulation strategy. Theophylline, an antiasthmatic is used as the model drug.

Methodology: Oral gastro retentive floating tablets of Theophylline was formulated using gel-forming hydrophilic polymers, HPMCK4M, HPMCK100M and HPMC 15cps. The work also focused on in vivo evaluation of buoyancy by x-ray imaging. Suitable In vitro methods for estimating the drug release from the tablet as a function of time were developed and compared with marketed product (Theo SR 200 mg)

Outcome: The prepared Tablets exhibited satisfactory physico chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablets with HPMCK4M and HPMCK100M floated for longer duration and had more matrix integrity as compared to formulations containing HPMC 15cps. Formulations with HPMCK 100 M & HPMCK 4 M showed better control of drug release and the drug release was similar to that of marketed product.  

Keywords: Theophylline, Gastro retentive floating tablets, Polymers HPMCK4M,HPMCK100M and HPMC 15cps.

C.Bijumol, Helen William, Jose Kurien and Thomas Kurian. Formulation and Evaluation of Floating tablets of Theophylline Hygeia.J.D.Med. 2013;5(1):23-31.Available from   http://www.hygeiajournal.com/ Article ID- Hygeia.J.D.Med/85/13


For Correspondence: bijumolc@yahoo.in
Hygeia.J.D.Med. Vol.5 (1), April 2013
© 2013, Hygeia journal for drugs and medicines,
All rights reserved.  2229 3590, 0975
Researcher ID: K 2890-2012



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