Abstract

Effect of fresh juice of Brassica oleracea Var. Capitata on isolated precontracted rat uterine horns

Kirti Patel V1*, Kalpana Patel G1,Tejas Mehta1, Tejal Gandhi R1, and Ramesh Goyal K2

Article history: Received: 24 July 2012,   revised: 10 August 2012, accepted: 10 September 2012, Available online:  October 2012

Page: 21-26 

Abstract

Plan:  The present study was undertaken to investigate the H₂ receptor antagonistic action offresh juice of Brassica oleracea var. capitata

Methodology: Two sets of experiments consisted of recording the responses of the uterine horn preparations (precontracted with potassium chloride, KCl) to histamine (4.5; 9;17.99; 35.99; 71.98 × 10^–4 and 14.40× 10^–3 mol/L, 2 minute each concentration) in absence and presence of S- Chlorpheniramine,ranitidine and BOCJ. Relaxant responses were measured as changes in isometric tension and converted into percentage of the reference maximum relaxation induced by standard dose of histamine for each group of experiment.

Outcome: Our results indicate that histamine (EC50 = 19.05 ± 1.76 × 10^-4 mol/L, p < 0.001)produces relaxation of potassium chloride precontracted isolated rat uterus. This effect of histamine is abolished by ranitidine, a selective H2 histamine receptor antagonist and BOCJ in a concentration dependent manner.   

Keywords: Brassica oleracea (BOCJ) histamine, uterus, relaxation

How to site this article: Kirti Patel V, Kalpana Patel G,Tejas Mehta, Tejal Gandhi R, and Ramesh Goyal K . Effect of fresh juice of Brassica oleracea Var. Capitata on isolated precontracted rat uterine horns. .Hygeia.J.D.Med 2012;4(2) :21-26.

How to site this URL:Kirti Patel V, Kalpana Patel G,Tejas Mehta, Tejal Gandhi R, and Ramesh Goyal K . Effect of fresh juice of Brassica oleracea Var. Capitata on isolated precontracted rat uterine horns. .Hygeia.J.D.Med 2012;4(2) :21-26. available from : http://www.hygeiajournal.com/Abstract.aspx?did=162