Abstract
Evaluation of Anti-inflammatory activity of acid Hydrazide derivatives
Rakesh Narang1,Sunil Sharma1, Balasubramanian Narasimhan2*
1.Department of Pharmaceutical Sciences, Guru Jambheshwar University of Scienceand Technology, Hisar 125001, India.
2. Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India.
Article history: Received: 20 June 2012, revised: 17 August 2012, accepted:26 August 2012, Available online:10October 2012
Page:15-20
Abstract
Plan: Anti-inflammatory evaluation of acid hydrazide derivatives.
Prologue: Hydrazide derivatives of organic compounds forms a significant group of derivatives which exhibit an arrayof biological activities like anti-inflammatory, antibacterial, anti fungal,anti-neoplastic, antiviral etc. In view of above facts, we hereby reported the anti-inflammatory evaluation of selected most active eight antimicrobial acid(nicotinic acid, naphthalene-1-acetic acid and 2-naphthoxy acetic acid)hydrazide derivatives.
Methodology: The anti-inflammatory activity of reported hydrazide derivatives determined by carrageenan induced paw oedema method and diclofenac sodium as standard drug.
Outcome: Anti-inflammatory activity showed that nicotinic acid hydrazide derivatives with NO2 substituents at ortho and meta position were the most active ones among the selected hydrazide derivatives, having 35.73% and 37.29%; 25.12% and 34.17%inhibition, at two different doses 20 mg/kg and 50 mg/kg b.w., respectively.
Keywords: Anti-inflammatory,Antimicrobial, Acid hydrazides
How to site this article:Rakesh Narang, Sunil Sharma ,Balasubramanian Narasimhan . Evaluation of Anti-inflammatory activity of acid Hydrazide derivatives.Hygeia.J.D.Med 2012;4(2) :15-20.
How to site this URL:Rakesh Narang, Sunil Sharma ,Balasubramanian Narasimhan . Evaluation of Anti-inflammatory activity of acid Hydrazide derivatives.Hygeia.J.D.Med 2012;4(2) :15-20.available from:http://www.hygeiajournal.com/Abstract.aspx?did=161
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Hygeia.J.D.Med.Vol.4 (2), Oct. 2012
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