Abstract
Simple Spectrofluorimetric determination of Buspirone hydrochloride in Bulk drug and Pharmaceutical dosage forms.
Jose Kurien, Thomas Kurian, HelenWilliam and Bijumol C.
College of Pharmaceutical Sciences, Govt. Medical College, Kottayam, Kerala, India-686 008.
Article history: Received: 22 June 2012, revised: 10 August 2012, accepted: 20 August2012, Available online: 10 October 2012
Page:6-14
Abstract
Plan: An analytical method for estimation of Buspirone HCl in bulk drug and pharmaceutical dosage forms by spectrofluorimetric is described.
Prologue: The method is simple, fast and accurate and can be used for routine analysis of commercial Buspirone HCl tablets.
Methodology: The developed method is based on the determination of fluorescence intensity of the solutions in water at 379nm after excitation at 238nm. Different experimental parameters affecting the fluorescence were carefully studied. The fluorescence intensityof the solution was stable for 5 hours. The calibration curve was linear from 50-1500 ng/ml. The limit of detection (LOD) and limit of quantification (LOQ)were 20ng/ml and 45ng/ml respectively.
Outcome: The proposed method has been applied successfully for the determination of BuspironeHCl in pharmaceutical dosage forms. No significant interference was observed from excipients, coloring and flavoring agents commonly used in the formulation. The mean recovery of drug from tablets was 99.89%.
Keywords: Buspirone HCl;Spectrofluorimetric method; Bulk/Pharmaceutical Dosage forms.
How to cite this article: Jose Kurien, Thomas Kurian, Helen William and Bijumol C. Simple Spectrofluorimetric determination of Buspirone hydrochloride.Hygeia.J.D.Med 2012;4(2):6-14.
How to cite this URL:
Jose Kurien, Thomas Kurian, Helen William and Bijumol C.Simple Spectrofluorimetric determination of Buspirone hydrochloride.Hygeia.J.D.Med 2012;4(2):6-14.available from: http://www.hygeiajournal.com/Abstract.aspx?did=160.
For Correspondence:
E mail: josekurien@gmail.com
Rid:G 9587-2012
Hygeia.J.D.Med.Vol.4 (2), Oct. 2012
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