Hygeia journal for drugs and medicines


Anti hyperlipidemic activity of Spirulina platensis in Triton x-100 induced hyperlipidemic rats.

Hygeia.JD.Med.Vol.3 (2),Oct.2011-March 2012, 32-37.


Articletitle: Antihyperlipidemic activity of Spirulinaplatensis in Triton x-100 induced hyperlipidemic rats.

Authors:S.S.Sudha*, R.Karthic, Naveen, J.Rengaramanujam

P.G and Research Dept ofMicrobiology, Dr.N.G.P. Arts and Science College, Kalapatti, Coimbatore,Tamilnadu, India.


Article history: Received: 02 April, 2011, revised: 14July2011, accepted: 25July 2011,Available online: 1October 2011


Hyperlipidemia is the greatest riskfactor of coronary heart disease. The present study was designed to investigatethe antihyperlipidemic activity of Spirulina platensis in Triton X-100 inducedHyperlipidemic rats. Spirulina platensis was administered at a dose of0.5gm/day, (p.o) to Triton induced Hyperlipidemic rats. Fenofibrate is used asreference standard. The statistical analyses were carried out using one wayANOVA followed by Dunnet’s multiple comparison test. S.platensis show asignificant decrease in the levels of serum cholesterol, phospholipids,triglycerides, LDL, VLDL and significant increase in the level of serum HDL atthe dose of 0.5gm/day (p.o) against Triton induced hyperlipidemic rats.Therefore it effectively suppressed the Triton induced hyperlipidemia in rats,suggesting the potential protective role in Coronary heart disease.

Key words: Spirulinaplatensis, Hyperlipidemia,Triglycerides, lipoprotein, Triton X-100.

Article out line


2.Materials and methods

3.Acute toxicity studies

4.Anti hyperlipidemic activity studies

5.Results and discussion

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SS Sudha*, R Karthic, Naveen, J RengaramanujamH.J.D.Med.vol.3 (2), October 2011,pp.32-37.

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