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Formulation, Evaluation and Optimization of Novel Silver Sulfadiazine Loaded Film Forming Hydrogel for Burns

Hygeia.J.D.Med. 2016; 8 (2):1-10

DOI:10.15254/H.J.D.Med.8.2016.156

Saranya TV, and Manoj K *

College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008

Received: 25 August 2016,
Revised: 20 September 2016
Accepted: 12 October 2016,
Available online: 30 November 2016

Plan: Formulation, evaluation and optimization of Silver sulfadiazine loaded film forming hydrogel using different hydrophilic polymers for the treatment of burns.

Preface: Burn injuries are very complex. One of the golden treatments in topical burn is silver sulfadiazine (SSD).The film forming hydrogels (FFHs) are non- solid dosage forms that produce a flexible, occlusive film in-situ after application on the skin or any other body surface.

Methodology: The hydrogel matrix was prepared with combinations of PVA & PVP, HPMC E5LV, and HPMC E15LV. The prepared FFHs were evaluated for their various physicochemical properties. The optimized formulation was selected by antimicrobial activity by agar diffusion technique. The in-vitro drug release study of optimized formulation was carried out and analyzed by potentiometric titrations.

Outcome: All the formulations showed better antimicrobial activity when compared with marketed SSD cream. The formulation F3 was found to be the optimized formulation.

Key words Film forming hydrogel, Silver sulfadiazine, Potentiometry

Article citation

Saranya TV, Manoj K *. Formulation, evaluation and optimization of novel silver sulfadiazine loaded film forming hydrogel for burns.Hygeia.J.D.Med. 2016; 8 (2):1-10. Available from http://www.hygeiajournal.com / Article ID-Hygeia.J.D.Med/156/16.DOI 10.15254/H.J.D.Med.8.2016.156.

SEM image of formulation F3 at 3000 magnification